mandom corp.

CSR Information

Mandom Group's CSR KohDoh Practices

Community Involvement and Development
"Approach to alternative to animal experiments"

Approach to alternative to animal experiments

At Mandom, based on the principles of animal welfare and the 3Rs* (especially "Replacement"), since 2005 we have been working to strengthen our internal system to develop replacements for animal experiments using three approaches. We will continue to work in this direction to meet the expectations of society.

Reference:

The Japanese Society for Alternatives to Animal Experiments

*3Rs:
Replacement (Using other methods that do not involve animals)
Reduction (Decrease the amount of use of animals)
Refinement (Lessen the suffering caused to animals)

Approach to alternative to animal experiments Approach to alternative to animal experiments

Mandom International Research Grants on Alternative to Animal Experiments

Mandom has been providing grants for research on alternatives to animal experiments since 2008. See below for more details.

Mandom International Research Grants on Alternative to Animal Experiments. (List of research themes)

12th (2019)
Name Takayuki Yoshimoto
Affiliation Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University
Research theme Development of a novel alternative method to animal experiments for evaluation of allergenic potential by human T cells
Name Huihui Wang
Affiliation China Medical University
Research theme Establishment and application of a cell-based high-throughput screening system for identification of cosmetics ingredient oxidative stressors
11th (2018)
Name Yasunari Kanda
Affiliation Division of Pharmacology, National Institute of health Sciences
Research theme Development of in vitro chemical safety assessment using human iPS cells
Name Takao Ashikaga
Affiliation Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences
Research theme Utility of the h-CLAT on the evaluation of respiratory sensitizer
Name Kumiko Tatsumi
Affiliation Department of Surgery, Graduate School of Medicine, Kyoto University
Research theme Development of hepatotoxicity evaluation model utilizing residual resected liver tissue derived from individual patients
10th (2017)
Name Shinji Sugiura
Affiliation Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)
Research theme Development of pressure driven multi-throughput organs-on-a-chip platform.
Name Kenji Usui
Affiliation Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Research theme Development of easy-to-use skin sensitization test for poorly water-soluble substances using peptidyl beads.
9th (2016)
Name Yuji Yoshiyama
Affiliation Kitasato University
Research theme Effects of hydrogen gas on H9c2 cardiomyocytes from ischemia reperfusion injury.
Name Kousei Ito
Affiliation Chiba University
Research theme Establishment of in vitro cell assay system of drug-induced liver injury risk compounds related to mitochondrial toxicity.
8th (2015)
Name Kouichi Yoshinari
Affiliation Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Research theme Development of the prediction method for repeated dose toxicity of chemical compounds based on the statistical data analysis using in vivo toxicity database and in vitro assays.
Name Seiichi Ishida
Affiliation National Institute of Health Sciences, Division of Pharmacology
Research theme Development of in vitro culture system mimicking human liver functionality by the co-culture of HepaRG, human hepatocyte progenitor cell line, and liverstellate cells.
7th (2014)
Name Toshihiro Ona
Affiliation Kyushu University
Research theme Development of universal method in skin stimulus measurement using epidermal keratinocyte mitochondria as a forefront of sensory system for homeostasis maintenance.
Name Takashi Yoshikado
Yuichi Sugiyama
Affiliation Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Research theme Prediction of the risk of drug-induced cholestasis based on the functional evaluation of bile canalicular transporters in vitro.
6th (2013)
Name Satoru Koyanagi
Affiliation Graduate School of Pharmaceutical Sciences, Kyushu University
Research theme Establishment of in vitro circadian clock system for evaluation of cell protecting mechanism against oncogenic transformation.
5th (2012)
Name Hisamitsu Hayashi
Affiliation Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme Search for new candidate drugs for Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2).
Name Hirokazu Kaji
Affiliation Graduate School of Engineering, Tohoku University
Research theme Development of a cell-based model of the retina within a microfluidic device.
4th (2011)
Name Jeong Ik Lee
Affiliation Konkuk University
Research theme Development of biomimetic tissues from commercial cell lines:
The promising alternative tools for laboratory animals.
Name Hideto Ariumi
Affiliation Kitasato University
Research theme Acetylcholine inhibits the hypoxia and hydrogen peroxide-induced reduction of connexin43 protein in rat cardiomyocytes.
Name Naoki Yamamoto
Affiliation Fujita Health University
Research theme A study of the eye irritation test using new immortalized human corneal epithelium.
3rd (2010)
Name Hiroyuki Kusuhara
Affiliation Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme Establishment of quantitative prediction of in vivo renal clearance based on in vitro data obtained using human derived materials and overexpression systems.
Name Masahiro Takagi
Affiliation Japan Advanced Institute of Science and Technology
Research theme Development of an Alternative method to Draize Test by Analysis of Biomimetic Membrane Dynamics.
2nd (2009)
Name Kikuo Komori
Affiliation Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme Formation and Functional Evaluation of a Minimum Cell Mass for in vitro Toxicity Tests.
Name Shigehiro Ohdo
Affiliation Graduate School of Pharmaceutical Sciences, Kyushu University
Research theme Establishment of chronopharmacokinetic evaluation system in vitro cultured cells:
Molecular basis for rhythmic expression of CYP in serum-shocked HepG2 cells.
Name Kazuya Maeda
Affiliation Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme Establishment of the methods for quantitative prediction of the detoxification activity of drugs and the risk of drug-drug interactions in the liver by the use of human liver samples and gene expression systems.
- Use of human-derived organ samples as alternatives of animal experiments -
1st (2008)
Name Kenji Sugibayashi
Affiliation Josai University
Research theme Permeation of several compounds through different three-dimensional cultured human skin models.
Name Tsutomu Kurosawa
Affiliation Osaka University
Research theme Establishment of the alternative method of animal experiment, using green fluorescent ES and iPS cells.
Name Jae Hak Park
Affiliation Seoul National University
Research theme International Validation of Bovine Corneal Opacity and Permeability (BCOP) assay and introduction of "MCTT Skin model" as an alternative to skin irritation test.
Name Lee Jeong Ik
Affiliation Tokai University
Research theme Study on the hazardous effects of intra-peritoneal injection of anesthetics on internal organs.
-Resolution on the mechanism of the direct hazard of anesthetic injection on cell lines derived from the liver cells and pancreatic islet cells in vitro-

Received Distinguished Service Award at the 30th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

At the 30th annual meeting of the Japanese Society for Alternatives to Animal Experiments in November 2017, our previous research grant activities were recognized for their major contribution to the Japanese Society for Alternatives to Animal Experiments, and we received the Distinguished Service Award from the society.
Through our research grants, Mandom will continue to widely recommend research in the area of alternatives to animal experiments. At the same time, we will contribute to society through participation in the committee activities of the society, promotion of validation initiatives with research institutions to achieve international standardization of new alternatives to animal experiments, and other efforts to further energize research in the alternatives field.

Reference:

PDFNovember 27, 2017, News Release "Mandom Receives Distinguished Service Award at the 30th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments" (Japanese only)(PDF:162KB)

Our Position on Animal Experiments

Mandom is working to develop cosmetics based
on a policy of no animal Experiments.

Mandom develops products with the safety of the consumer as our top priority. Fundamentally, the safety testing of our products is to be done on people (patch tests, stinging tests, etc.) and by using alternatives to animal Experiments. No animal Experiments is to be performed, which includes outsourcing. No animal testing will remain our policy in the future.

* This excludes instances where we are held responsible by society to evidence the safety of a product or where it is required by administrations in particular countries

We are grateful for the valuable opinions expressed by our stakeholders, and will reflect them in product development that is both safe and eco-friendly.